Bruton's tyrosine kinase (Btk), a member of the non-receptor tyrosine kinase Tec family, is a key signaling enzyme expressed in all hematopoietic cell types except T lymphocytes and natural killer cells.Btk plays a crucial role in stimulating B cell signaling pathways that connect the cell surface B cell receptor (BCR) to the downstream intracellular response.
The main levels of BTK inhibitor are divided into Irreversible Inhibitor and Reversible Inhibitor according to therapeutic options.
Bruton tyrosine kinase (BTK) is a key kinase in the signaling pathway of B cell antigen receptor (BCR). Since BTK deficiency mainly affects B cells, BTK naturally becomes an attractive therapeutic target in autoimmune diseases and b-cell malignancies.Many companies are beginning to design kinase-selective inhibitors that target the molecular structure and function of BTK.
Figure BTK Inhibitor Mechanism of Action
Irreversible inhibitors, like all ATP competitive reversible inhibitors, are generally able to compete to occupy the atp-kinase binding cavity.In theory, these inhibitors have infinitely strong binding activity and complete blocking of signaling pathways, and their pharmacodynamic properties are basically independent of their pharmacokinetic advantages, thus greatly improving the utilization efficiency of drugs.
Reversible inhibitors, which are characterized by their ability to competitively occupy the Spaces where ATP binds to kinases, then complete the process of binding to and breaking off from the enzyme within 10 to 15 minutes of drug metabolism, thus achieving a balance.Their effect on target proteins is therefore "transient" relative to that of irreversible inhibitors.Its advantage is that it will not cause permanent damage to the target protein, but only temporarily interfere with its physiological state.
. k. O% f$ h) c* N2 x* f' uThe major Irreversible inhibitorsplayer in the market
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In addition to the mainstream Irreversible Inhibitors systems of various manufacturers, each manufacturer also has different models and functions of Reversible inhibitors
The major REVERSIBLE INHIBITORS player in the market
The BTK inhibitor originated in America and rose in Europe and Asia-Pacific. The United States currently accounts for 53% of the global BTK inhibitor market. After BTK inhibitor was discovered for the first time In 1993, Beijing Sailintai Medicine, Onepharm/Gliead, Principiabiopharma Bristol-myers Squibb, Merck , Lilly/Hanmi ,Roche, Takeda, Biological Principiabiopharma Eisen, Zhejiang Ming Guide Medicine Science and Technology, Jiangsu Hengrui developed one after another. The BTK inhibitor is used in Non-hodgkin's lymphoma (NHL), Wm. Abc-Dlbcl, MMMCL, Fahrenheit macroglobulinemia, b-cell lymphoma, b-cell lymphoma, Sjogren's Syndrome, Scarring Ulcer Vulva Rheumatoid Arthritis MCL, CLL rheumatoid arthritis autoimmune diseases.
Figure Major BTK Inhibitors Have Been Approved Or Are Under Clinical Development Worldwide
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According to 2019 data released by the CAP, the global market for BTK inhibitors is $5.4 billion. Most markets are concentrated in developed countries such as North America and Europe.
Figure Revenue Market Share of BTK inhibitor by Regions in 2015
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In recent years, with the continuous development of biotechnology and drug development in emerging markets, other countries except Europe and the United States are also growing rapidly. The United States became the main market for BTK inhibitor, while the population of the BRIC countries with large populations is also increasing the demand for BTK inhibitor.
Figure Revenue Market Share of BTK Inhibitor by Regions in 2019
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Ibrutinib was launched in China in 2017 for the treatment of relapsed refractory CLL/SLL, refractory MCL and WM, and was listed in the national directory of medicare at the end of 2018. It is the only BTK inhibitor sold in China as of September 30, 2019. China is the fastest growing market in this area. Baiji shenzhou has carried out Zanubrutinib and Ibrutinib on the two indications of WM and CLL. In addition to baiji shenzhou, btk-targeted drugs of many domestic pharmaceutical companies, including nuocheng jianhua, hengrui pharmaceutical, zhejiang dawing and Xinovi, have entered the clinical stage and are expected to be launched after 2020.
[url=]Figure Global BTK Inhibitor Revenue (Million US$) Growth Rate (2015-2026)[/url]
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Osimertinib has greater target inhibition and selectivity than other approved BTK inhibitors.
Osimertinib Mechanism of Action In B-Cell Malignancy
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Reversible Inhibitors price is high, and the number of target customers is small: a set of
Irreversible Inhibitors prices are over five hundred of dollars per 10mg packed , only applicable to research.
Irreversible Inhibitors can be flexibly combined according to specific needs, suitable for most hospitals, biochemical immune cascade running.
With industry-standard accuracy in analysis and high data integrity, the report makes a brilliant attempt to unveil key opportunities available in the global Bruton's Tyrosine Kinase (Btk) Inhibitors market to help players in achieving a strong market position. Buyers of the report can access verified and reliable market forecasts, including those for the overall size of the global Bruton's Tyrosine Kinase (Btk) Inhibitors market in terms of revenue.
Players, stakeholders, and other participants in the global Bruton's Tyrosine Kinase (Btk) Inhibitors market will be able to gain the upper hand as they use the report as a powerful resource. For this version of the report, the segmental analysis focuses on revenue and forecast by each application segment in terms of revenue and forecast by each type segment in terms of revenue for the period 2015-2026.
Regional and Country-level Analysis
The report offers an exhaustive geographical analysis of the global Bruton's Tyrosine Kinase (Btk) Inhibitors market, covering important regions, viz, North America, Europe, China, Japan, Southeast Asia, India and Central & South America. It also covers key countries (regions), viz, U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, UAE, etc.
The report includes country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by each application segment in terms of revenue for the period 2015-2026.
Competition Analysis
In the competitive analysis section of the report, leading as well as prominent players of the global Bruton's Tyrosine Kinase (Btk) Inhibitors market are broadly studied on the basis of key factors. The report offers comprehensive analysis and accurate statistics on revenue by the player for the period 2015-2020. It also offers detailed analysis supported by reliable statistics on price and revenue (global level) by player for the period 2015-2020.
On the whole, the report proves to be an effective tool that players can use to gain a competitive edge over their competitors and ensure lasting success in the global Bruton's Tyrosine Kinase (Btk) Inhibitors market. All of the findings, data, and information provided in the report are validated and revalidated with the help of trustworthy sources. The analysts who have authored the report took a unique and industry-best research and analysis approach for an in-depth study of the global Bruton's Tyrosine Kinase (Btk) Inhibitors market.
The following players are covered in this report:
Johnson & Johnson
AstraZeneca
Roche
Sunesis
Takeda
Bristol- Myers Squibb
Gilead Sciences
AbbVie
Biogen
INNOCARE
ACEA Biosciences
Acerta Pharma
Aptose Biosciences
ArQule
BeiGene
Carna Biosciences
Celgene Corporation
Eternity Bioscience
Hanmi Pharmaceutical
KBP Biosciences
Loxo Oncology
LSK BioPharma
Merck
Ono Pharmaceutical
Pharmacyclics
Principia Biopharma
Tolero
X-Rx
Zhejiang DTRM Biopharma
Bruton's Tyrosine Kinase (Btk) Inhibitors Breakdown Data by Type
IC50<1nM
1nM< IC50<5nM
IC50＞5nM
Bruton's Tyrosine Kinase (Btk) Inhibitors Breakdown Data by Application
Chronic Lymphocytic Leukemia (cll)
Follicular Lymphoma
Mantle Cell Lymphoma
Marginal Zone Lymphoma
Small Lymphocytic Lymphoma
Waldenstrom Macroglobulinemia
Other Selective B Cell Malignancies
Chronic Graft-versus-host Disease
Other
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